Waters oligonucleotide separation technology delivers exceptional sample resolution and superior column life. In addition, Waters manufacturing and quality control testing procedures help ensure consistent batch-to-batch and column-to-column performance regardless of application demands. Chromatography of synthetic oligonucleotides and DNA / RNA species of less than approximately 12,000 base pairs can be satisfactorily performed using reversed-phase or ion-exchange gradient techniques capable of resolving sample components based on minor changes in size (i.e., charge).