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ACQUITY UPLC System

The ACQUITY UPLC System lets you achieve higher UPLC/UHPLC chromatographic resolution and sensitivity and greater throughput using sub-2-µm particle technology. This is the original UPLC system featuring binary solvent management.
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UPLC transforms the expectations of laboratories worldwide

UPLC Technology, which has been adopted successfully in laboratories around the world for the most demanding separations, is highly robust, dependable, and reproducible.

Work at higher efficiencies with a much wider range of linear velocities, flow rates, and backpressures
Higher flow rates and increased throughput result in superior resolution and sensitivity
Eliminate significant time and cost per sample, while improving quality of results
Benefit from Waters’ patented sub-2-μm hybrid particle chemistry

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Harness the efficiency power of sub-2-μm particles with ACQUITY UPLC Columns. Achieve increases in resolution, sensitivity, accuracy, speed, reliability, and robustness.
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Quantitative compounds with visible wavelength maxima up to 800 nm and achieve higher sensitivity levels with high resolution spectra for peak identification and purity analysis.
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A dual-wavelength ultraviolet/visible detector optimized for UltraPerformance LC (UPLC). It offers optimal linearity, resolution and sensitivity for UPLC/UV separations.
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Provides sensitive, selective detection for UPLC-based fluorescence applications.
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Low-dispersion detection for the isocratic analysis of analytes that lack a UV chromophore, such as in the analysis of polymers. Delivers high sensitivity, baseline stability and repeatable integration of narrow UPLC peaks.
ACQUITY UPLC ELS Detector
Designed for optimal UPLC/ELS performance in a small footprint.
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Add spectral conformation to your absorbance detection methods while still maintaining high sensitivity and a wide linear dynamic range.
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A versatile, dual-wavelength absorbance detector that offers simplicity for routine UV-based applications and high sensitivity for low-level impurity analysis.
2475 Fluorescence (FLR) Detector
Delivers unsurpassed sensitivity and selectivity for quantifying low concentrations of target compounds, whether naturally fluorescent or derivatized with a fluorescent tag.
2414 Refractive Index (RI) Detector
Offers high sensitivity, stability, and reproducibility, making this detector the ideal solution for the isocratic analysis of components with limited or no UV absorption.
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Add spectral conformation to your absorbance detection methods while still maintaining high sensitivity and a wide linear dynamic range.
2424 Evaporative Light Scattering (ELS) Detector for Purification and Modular LC Systems
A complementary detection technique for semi- and non-volatile compounds with little or no UV absorbance. Compatible with both isocratic and gradient methods.
2414 Refractive Index (RI) Detector for Modular LC Systems
Offers high sensitivity, stability, and reproducibility, making this detector the ideal solution for the isocratic analysis of components with limited or no UV absorption.
2475 Fluorescence (FLR) Detector for Modular LC Systems
Delivers unsurpassed sensitivity and selectivity for quantifying low concentrations of target compounds, whether naturally fluorescent or derivatized with a fluorescent tag.
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Waters leads the way in amino acid analysis by bringing together its most groundbreaking, popular technologies – ACQUITY UPLC and AccQ•Tag Ultra – to create the UPLC Amino Acid Analysis Application Solution.
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CORTECS Columns
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XBridge BEH Columns for UHPLC/HPLC for high pH HPLC, and other extreme conditions, ideal for method development. Chemistries include C18, C8, Shield RP18, Phenyl, HILIC & Amide.
XSelect Columns
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VanGuard Column Protection
VanGuard Pre-columns and cartridges for prolonging analytical HPLC column lifetime while maintaining chromatographic performance.
UHPLC Columns
Our focused selection of UHPLC columns highlight the performance advantages modern UHPLC instrumentation.
Symmetry Columns
HPLC columns with high purity silica and tightly controlled manufacturing processes to ensure batch to batch reproducibility and superior peak shapes. Chemistries include C18, C4, C8, Shield RP18, Shield RP8.
Bioseparations Columns & Consumables
Chemistry consumables for the accurate analysis of peptides, proteins, oligonucleotides, glycans and amino acids
Atlantis Columns
Analytical and preparative HPLC columns for stable polar compound retention of broad analyte mixtures. Chemistries include C18, T3, HILIC and dc18.
SunFire Columns
Chromatography columns in analytical / preparative dimensions and designed for high mass loading capability, low pH stability, and high efficiency. Chemistries include C18 and C8.
XTerra Columns
Analytical and preparative LC columns for high pH drug discovery, method development and purification separations. Chemistries include C18, C8 and Phenyl.
Nova-Pak Columns
Columns that offer high resolution as well as faster and more efficient chromatography. Chemistries include C18, C8, Cyano, and Phenyl.
Waters Spherisorb Columns
Columns for different and unique separation selectivities, widely published for analytical and preparative HPLC. Chemistries include C18, Amino (NH2), C1, C6, C8, Cyano (CN), Phenyl, SAX, SCX, ODS1, and ODS2.
Resolve Columns
Non-end capped columns providing high retention of polar compounds and high resolution. Chemistries include C18, C8 and Cyano (CN).
µBondapak - Bondapak
Ideal for the separation of acidic, basic, and neutral compounds making them widely useful for preparative chromatography. Chemistries include C18, Phenyl, Cyano (CN), and NH2.
µPorasil/Porasil Columns
QC tool for scalability for preparative high performance liquid chromatography.
Waters PAH Columns
For improved analysis of PAH Polyaromatic hydrocarbons (PAHs) compounds. Chemistries include C18.
Protein-Pak Columns
HPLC IEX, HIC, Affinity HPLC-based columns intended for high-quality analysis or lab scale isolation of proteins or polypeptides. Chemistries include affintiy, anion-exchange, cation-exchange, SAX, and SEC.
Shodex RSPak Columns
Polymeric reversed-phase columns for applications requiring broad pH range (2-12) ideal for basic compounds as well as different selectivity from silica-based columns. Chemistries include DE-613.
BioSuite Columns
HPLC columns ideally suited for the isolation, analysis, and characterization of proteins and peptides. Chemistries include C18, anion-exchange, cation-exchange, high resolution SEC, Phenyl, SEC and ultra high resolution SEC.
Accessories
Waters offers a variety of tubings, fittings, column connections, and replacement parts for columns and cartridges.

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